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Psychopharmacology (Berl). 2017 Feb;234(3):403-420. doi: 10.1007/s00213-016-4471-y. Epub 2016 Dec 5.

Reduced inattention and hyperactivity and improved cognition after marine oil extract (PCSO-524®) supplementation in children and adolescents with clinical and subclinical symptoms of attention-deficit hyperactivity disorder (ADHD): a randomised, double-blind, placebo-controlled trial.

Author information

1
Centre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218 (H24), Hawthorn, VIC, 3122, Australia.
2
Department of Psychiatry, Melbourne Clinic, University of Melbourne, Melbourne, Australia.
3
Centre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218 (H24), Hawthorn, VIC, 3122, Australia. cstough@swin.edu.au.

Abstract

INTRODUCTION:

This study investigated the effects of a marine oil extract (PCSO-524®) on inattention, hyperactivity, mood and cognition in children and adolescents. PCSO-524® is a standardised lipid extract of the New Zealand green-lipped mussel and is an inflammatory modulator that inhibits the 5'-lipoxygenase and cyclooxygenase pathways and decreases concentrations of the pro-inflammatory arachidonic acid (AA).

METHODS:

PCSO-524® or a matched placebo was administered for 14 weeks to 144 participants (123 males/21 females; mean age 8.7 years) with high hyperactivity and inattention in a randomised, double-blind, placebo-controlled study. The primary outcome was the Conners Parent Rating Scale assessing parental reports of behavioural problems. Secondary outcomes assessed changes in cognition and mood.

RESULTS:

The results of the present study did not support the hypothesis that PCSO-524® improves parental reports of hyperactivity, inattention and impulsivity in children ages 6 to 14 years over placebo. Repeated measures ANOVA on post hoc subsample analysis indicated significant improvements in hyperactivity (p = 0.04), attention (p = 0.02), learning (p = 0.05) and probability of ADHD (p = 0.04) with a medium to large average effect size (d = 0.65) in those children who did not meet criteria for combined hyperactivity and inattention. Furthermore, significant improvements in the PCSO-524® group were indicated in a whole sample repeated measures ANCOVA on recognition memory between baseline and week 8 over placebo (p = 0.02, d = 0.56); this difference was not sustained at week 14.

CONCLUSIONS:

The results presented indicate that PCSO-524® may be beneficial in reducing levels of hyperactivity and inattention in a population of children with clinical and subclinical symptoms of ADHD.

KEYWORDS:

ADHD; Attention; Children; Cognition; Green-lipped mussel; Hyperactivity; Marine oil; Mood; Omega-3

PMID:
27921139
PMCID:
PMC5225177
DOI:
10.1007/s00213-016-4471-y
[Indexed for MEDLINE]
Free PMC Article

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