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Int J Reprod Biomed (Yazd). 2016 Oct;14(10):625-628.

Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study.

Author information

1
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Repeated implantation failure (RIF) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one.

OBJECTIVE:

This study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in RIF patients.

MATERIALS AND METHODS:

Twenty women with a history of RIF who were candidates for frozen-thawed embryo transfer were recruited in this study. Intrauterine infusion of 0.5 ml of platelet-rich plasma that contained platelet 4-5 times more than peripheral blood sample was performed 48 hrs before blastocyst transfer.

RESULTS:

Eighteen participants were pregnant with one early miscarriage and one molar pregnancy. Sixteen clinical pregnancies were recorded and their pregnancies are ongoing.

CONCLUSION:

According to this study, it seems that platelet-rich plasma is effective in improvement of pregnancy outcome in RIF patients.

KEYWORDS:

Fertilization in Vitro; Implantation; Platelet-rich plasma; Pregnancy rate; Repeated implantation failure

PMID:
27921085
PMCID:
PMC5124324

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