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ACG Case Rep J. 2016 Nov 23;3(4):e162. eCollection 2016 Aug.

Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy.

Author information

1
Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA.
2
Department of Pathology, University of California San Francisco, San Francisco, CA.
3
Department of Medicine, Division of Hematology and Oncology, University of California San Francisco, San Francisco, CA.
4
Organ Transplant Department, Swedish Medical Center, Seattle, WA.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver failure (ALF). We discuss the diagnosis of HLH and Kikuchi-Fujimoto (KF) lymphadenitis in the context of pregnancy and ALF. HLH may respond to comorbid disease-specific therapy, and more toxic treatment can be avoided.

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