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Front Integr Neurosci. 2016 Nov 22;10:38. eCollection 2016.

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.

Author information

1
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida Gainesville, FL, USA.
2
Department of Neurology, and Neuroethics Studies Program, Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center Washington, DC, USA.
3
Department of Neurosurgery, Center for Neuromodulation, New York University Langone Medical Center New York, NY, USA.
4
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of FloridaGainesville, FL, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of FloridaGainesville, FL, USA.
5
Department of Neurology, Mayo Clinic Rochester, MN, USA.
6
Department of Bioengineering, Scientific Computing and Imaging Institute, University of Utah Salt Lake City, UT, USA.
7
Department of Neurosurgery, University of Kentucky Chandler Medical Center Lexington, KY, USA.
8
Department of Psychiatry, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
9
Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA.
10
Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, The University of Queensland Brisbane, QLD, Australia.
11
Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center Lexington, KY, USA.
12
Departments of Psychiatry and Behavioral Sciences and Radiology and Radiological Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
13
Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center Phoenix Arizona, AZ, USA.
14
Department of Neurology and Department of Biomedical Engineering, University of Alabama at Birmingham Birmingham, AL, USA.
15
Departments of Neurology and Neurological Sciences and Neurosurgery, Stanford University Stanford, CA, USA.
16
Department of Psychiatry, Emory University School of Medicine Atlanta, GA, USA.
17
Electrical Engineering Department, University of WashingtonSeattle, WA, USA; NSF Engineering Research Center for Sensorimotor Neural EngineeringSeattle, WA, USA.
18
Department of Neurosurgery, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA.
19
Department of Neurology, University Clinic of Würzburg Würzburg, Germany.
20
Department of Neurology, University of California San Francisco San Francisco, CA, USA.
21
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida Gainesville, FL, USA.
22
Department of Neurology, Baylor College of Medicine Houston, TX, USA.
23
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of FloridaGainesville, FL, USA; Department of Neurological Sciences, University of FloridaGainesville, FL, USA.
24
Departments of Neurological Sciences, Diagnostic Radiology, and Nuclear Medicine, Rush University Medical Center Chicago, IL, USA.
25
Division of Functional Neurosurgery, Department of Neurosurgery, Allegheny General Hospital Pittsburgh, PA, USA.
26
Department of Neurology, New York University Langone Medical Center New York, NY, USA.
27
Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine Baltimore, MD, USA.
28
Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco San Francisco, CA, USA.
29
Medtronic Modulation Minneapolis, MN, USA.
30
Movement Disorders Program, Department of Neurology, Alpert Medical School, Rhode Island Hospital, Brown University Providence, RI, USA.
31
Department of Biomedical Engineering, Duke University Durham, NC, USA.

Abstract

This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome. Next, advances in the use of neuroimaging and electrochemical markers to enhance DBS specificity were addressed. Updates on ongoing use and developments of DBS for the treatment of Parkinson's disease, essential tremor, Alzheimer's disease, depression, post-traumatic stress disorder, obesity, addiction were presented, and progress toward innovation(s) in closed-loop applications were discussed. Each section of these proceedings provides updates and highlights of new information as presented at this year's international Think Tank, with a view toward current and near future advancement of the field.

KEYWORDS:

Alzheimer's disease; DARPA; Parkinson's disease; Tourette syndrome; closed-loop; deep brain stimulation; depression; post-traumatic stress disorder

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