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Plant Cell. 2016 Dec;28(12):2937-2951. doi: 10.1105/tpc.16.00656. Epub 2016 Dec 5.

The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots.

Author information

1
Plant Developmental Biology, Wageningen University and Research Centre, Wageningen 6708PB, The Netherlands.
2
Bioinformatics Group, Wageningen University and Research Centre, Wageningen 6708PB, The Netherlands.
3
Applied Bioinformatics, Bioscience, Plant Research International, Wageningen University and Research Centre, Wageningen 6708PB, The Netherlands.
4
Theoretical Biology and Bioinformatics, Utrecht University, Utrecht 3584 CH, The Netherlands.
5
Molecular Genetics, Department of Biology, Utrecht University, Utrecht 3584 CH, The Netherlands.
6
Biosystematics Group, Wageningen University and Research Centre, 6708PB Wageningen, The Netherlands.
7
Laboratory of Biochemistry, Graduate School of Bioagricultural Science, Nagoya University, Nagoya 464-8601, Japan.
8
Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå SE-901 83, Sweden.
9
Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht 3584 CT, The Netherlands.
10
Hartwig Medical Foundation, 1098 XH Amsterdam, The Netherlands.
11
Department of Medical Genetics, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
12
Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland.
13
Department of Plant Biology, University of Georgia, Athens, Georgia 30602-7271.
14
Plant Developmental Biology, Wageningen University and Research Centre, Wageningen 6708PB, The Netherlands ben.scheres@wur.nl renze.heidstra@wur.nl.

Abstract

Organ formation in animals and plants relies on precise control of cell state transitions to turn stem cell daughters into fully differentiated cells. In plants, cells cannot rearrange due to shared cell walls. Thus, differentiation progression and the accompanying cell expansion must be tightly coordinated across tissues. PLETHORA (PLT) transcription factor gradients are unique in their ability to guide the progression of cell differentiation at different positions in the growing Arabidopsis thaliana root, which contrasts with well-described transcription factor gradients in animals specifying distinct cell fates within an essentially static context. To understand the output of the PLT gradient, we studied the gene set transcriptionally controlled by PLTs. Our work reveals how the PLT gradient can regulate cell state by region-specific induction of cell proliferation genes and repression of differentiation. Moreover, PLT targets include major patterning genes and autoregulatory feedback components, enforcing their role as master regulators of organ development.

PMID:
27920338
PMCID:
PMC5240741
DOI:
10.1105/tpc.16.00656
[Indexed for MEDLINE]
Free PMC Article

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