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J Infect Dis. 2016 Dec 15;214(suppl 5):S446-S448.

Chikungunya Pathogenesis: From the Clinics to the Bench.

Author information

1
UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, St. Denis, France.
2
National Health Institute, Public Health Research Division, Bogotá.
3
Division of Health Sciences, Faculty of Medicine, Universidad del Norte and Hospital Universidad del Norte, Barranquilla, Colombia.

Abstract

Chikungunya alphavirus has caused large epidemics worldwide and leads to acute incapacitating polyarthralgia. The inflammatory reaction over several days will drive robust innate and humoral responses essential to control the infection. Critically, fatal cases and mother-to-child transmission have also been described. Chikungunya can give rise to chronic musculoskeletal diseases, which can last for months to years, particularly in elderly individuals, and occasionally leads to seronegative rheumatoid arthritis-like pathologies. Histopathological studies of patient biopsy specimens and animal models have revealed that chikungunya virus can hide in tissue sanctuaries, and ongoing research should help to decipher the inflammatory mechanisms of tissue injuries.

KEYWORDS:

alphavirus; arthritis; encephalitis; inflammation; innate immunity; polyarthralgia

PMID:
27920171
DOI:
10.1093/infdis/jiw362
[Indexed for MEDLINE]

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