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Gynecol Oncol. 2017 Feb;144(2):396-404. doi: 10.1016/j.ygyno.2016.11.019. Epub 2016 Dec 2.

Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2).

Collaborators (494)

Bouzbid S, Hamdi-Chérif M, Zaidi Z, Bah E, Swaminathan R, Nortje SH, El Mistiri MM, Bayo S, Malle B, Manraj SS, Sewpaul-Sungkur R, Fabowale A, Ogunbiyi OJ, Bradshaw D, Somdyala NIM, Stefan DC, Abdel-Rahman M, Jaidane L, Mokni M, Kumcher I, Moreno F, González MS, Laura EA, Espinola SB, Calabrano GH, Carballo Quintero B, Fita R, Garcilazo DA, Giacciani PL, Diumenjo MC, Laspada WD, Green MA, Lanza MF, Ibañez SG, Lima CA, Lobo de Oliveira E, Daniel C, Scandiuzzi C, De Souza PCF, Melo CD, Del Pino K, Laporte C, Curado MP, de Oliveira JC, Veneziano CLA, Veneziano DB, Latorre MRDO, Tanaka LF, Azevedo E Silva G, Galaz JC, Moya JA, Herrmann DA, Vargas S, Herrera VM, Uribe CJ, Bravo LE, Arias-Ortiz NE, Jurado DM, Yépez MC, Galán YH, Torres P, Martínez-Reyes F, Pérez-Meza ML, Jaramillo L, Quinto R, Cueva P, Yépez JG, Torres-Cintrón CR, Tortolero-Luna G, Alonso R, Barrios E, Nikiforuk C, Shack L, Coldman AJ, Woods RR, Noonan G, Turner D, Kumar E, Zhang B, McCrate FR, Ryan S, Hannah H, Dewar RAD, MacIntyre M, Lalany A, Ruta M, Marrett L, Nishri DE, McClure C, Vriends KA, Bertrand C, Louchini R, Robb KI, Stuart-Panko H, Demers S, Wright S, George JT, Shen X, Brockhouse JT, O'Brien DK, Ward KC, Almon L, Bates J, Rycroft R, Mueller L, Phillips C, Brown H, Cromartie B, Schwartz AG, Vigneau F, MacKinnon JA, Wohler B, Bayakly AR, Clarke CA, Glaser SL, West D, Green MD, Hernandez BY, Johnson CJ, Jozwik D, Charlton ME, Lynch CF, Huang B, Tucker TC, Deapen D, Liu L, Hsieh MC, Wu XC, Stern K, Gershman ST, Knowlton RC, Alverson J, Copeland GE, Rogers DB, Lemons D, Williamson LL, Hood M, Hosain GM, Rees JR, Pawlish KS, Stroup A, Key C, Wiggins C, Kahn AR, Schymura MJ, Leung G, Rao C, Giljahn L, Warther B, Pate A, Patil M, Schubert SS, Rubertone JJ, Slack SJ, Fulton JP, Rousseau DL, Janes TA, Schwartz SM, Bolick SW, Hurley DM, Richards J, Whiteside MA, Nogueira LM, Herget K, Sweeney C, Martin J, Wang S, Harrelson DG, Keitheri Cheteri MB, Farley S, Hudson AG, Borchers R, Stephenson L, Espinoza JR, Weir HK, Edwards BK, Wang N, Yang L, Chen JS, Song GH, Gu XP, Zhang P, Ge HM, Zhao DL, Zhang JH, Zhu FD, Tang JG, Shen Y, Wang J, Li QL, Yang XP, Dong J, Li W, Cheng LP, Chen JG, Huang QH, Huang SQ, Guo GP, Wei K, Chen WQ, Zeng H, Demetriou AV, Pavlou P, Mang WK, Ngan KC, Swaminathan R, Kataki AC, Krishnatreya M, Jayalekshmi PA, Sebastian P, Sapkota SD, Verma Y, Nandakumar A, Suzanna E, Keinan-Boker L, Silverman BG, Ito H, Nakagawa H, Hattori M, Kaizaki Y, Sugiyama H, Utada M, Katayama K, Narimatsu H, Kanemura S, Koike T, Miyashiro I, Yoshii M, Oki I, Shibata A, Matsuda T, Nimri O, Ab Manan A, Bhoo-Pathy N, Tuvshingerel S, Chimedsuren O, Al Khater AHM, El Mistiri MM, Al-Eid H, Jung KW, Won YJ, Chiang CJ, Lai MS, Suwanrungruang K, Wiangnon S, Daoprasert K, Pongnikorn D, Geater SL, Sriplung H, Eser S, Yakut CI, Hackl M, Mühlböck H, Oberaigner W, Zborovskaya AA, Aleinikova OV, Henau K, Van Eycken L, Dimitrova N, Valerianova Z, Šekerija M, Zvolský M, Engholm G, Storm H, Innos K, Mägi M, Malila N, Seppä K, Jégu J, Velten M, Cornet E, Troussard X, Bouvier AM, Faivre J, Guizard AV, Bouvier V, Launoy G, Arveux P, Maynadié M, Mounier M, Fournier E, Woronoff AS, Daoulas M, Clavel J, Le Guyader-Peyrou S, Monnereau A, Trétarre B, Colonna M, Cowppli-Bony A, Molinié F, Bara S, Degré D, Ganry O, Lapôtre-Ledoux B, Grosclaude P, Estève J, Bray F, Piñeros M, Sassi F, Stabenow R, Eberle A, Erb C, Nennecke A, Kieschke J, Sirri E, Kajueter H, Emrich K, Zeissig SR, Holleczek B, Eisemann N, Katalinic A, Brenner H, Asquez RA, Kumar V, Ólafsdóttir EJ, Tryggvadóttir L, Comber H, Walsh PM, Sundseth H, Devigili E, Mazzoleni G, Giacomin A, Bella F, Castaing M, Sutera A, Gola G, Ferretti S, Serraino D, Zucchetto A, Lillini R, Vercelli M, Busco S, Pannozzo F, Vitarelli S, Ricci P, Pascucci C, Autelitano M, Cirilli C, Federico M, Fusco M, Vitale MF, Usala M, Cusimano R, Mazzucco W, Michiara M, Sgargi P, Maule MM, Sacerdote C, Tumino R, Di Felice E, Vicentini M, Falcini F, Cremone L, Budroni M, Cesaraccio R, Contrino ML, Tisano F, Fanetti AC, Maspero S, Candela G, Scuderi T, Gentilini MA, Piffer S, Rosso S, Sacchetto L, Caldarella A, La Rosa F, Stracci F, Contiero P, Tagliabue G, Dei Tos AP, Zorzi M, Zanetti R, Baili P, Berrino F, Gatta G, Sant M, Capocaccia R, De Angelis R, Liepina E, Maurina A, Smailyte G, Agius D, Calleja N, Siesling S, Visser O, Larønningen S, Møller B, Dyzmann-Sroka A, Trojanowski M, Góźdż S, Mężyk R, Grądalska-Lampart M, Radziszewska AU, Didkowska JA, Wojciechowska U, Błaszczyk J, Kępska K, Bielska-Lasota M, Kwiatkowska K, Forjaz G, Rego RA, Bastos J, Silva MA, Antunes L, Bento MJ, Mayer-da-Silva A, Miranda A, Coza D, Todescu AI, Valkov MY, Adamcik J, Safaei Diba C, Primic-Žakelj M, Žagar T, Stare J, Almar E, Mateos A, Quirós JR, Bidaurrazaga J, Larrañaga N, Díaz García JM, Marcos AI, Marcos-Gragera R, Vilardell Gil ML, Molina E, Sánchez MJ, Franch Sureda P, Ramos Montserrat M, Chirlaque MD, Navarro C, Ardanaz EE, Moreno-Iribas CC, Fernández-Delgado R, Peris-Bonet R, Galceran J, Khan S, Lambe M, Camey B, Bouchardy C, Usel M, Ess SM, Herrmann C, Bulliard JL, Maspoli-Conconi M, Frick H, Kuehni CE, Schindler M, Bordoni A, Spitale A, Chiolero A, Konzelmann I, Dehler SI, Matthes KL, Rashbass J, Stiller CA, Fitzpatrick D, Gavin A, Bannon F, Black RJ, Brewster DH, Huws DW, White C, Finan P, Allemani C, Bonaventure A, Carreira H, Coleman MP, Di Carlo V, Harewood R, Liu K, Matz M, Montel L, Nikšić M, Rachet B, Sanz N, Spika D, Stephens R, Peake M, Chalker E, Newman L, Baker D, Soeberg MJ, Aitken J, Scott C, Stokes BC, Venn A, Farrugia H, Giles GG, Threlfall T, Currow D, You H, Hendrix J, Lewis C.

Abstract

OBJECTIVE:

Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival.

METHODS:

The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15-99years) diagnosed with ovarian cancer during 1995-2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survival for each country by histological group. We also analysed data from 67 cancer registries for 233,659 women diagnosed from 2001 to 2009, for whom information on stage at diagnosis was available. We estimated age-standardised 5-year net survival by stage at diagnosis (localised or advanced).

RESULTS:

Survival from type I epithelial ovarian tumours for women diagnosed during 2005-09 ranged from 40 to 70%. Survival from type II epithelial tumours was much lower (20-45%). Survival from germ cell tumours was higher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cord stromal tumours was higher than for the five other groups. Survival from localised tumours was much higher than for advanced disease (80% vs. 30%).

CONCLUSIONS:

There is wide variation in survival between histological groups, and stage at diagnosis remains an important factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporate histology.

KEYWORDS:

epidemiology; histology; morphology; ovarian cancer; stage; survival

PMID:
27919574
DOI:
10.1016/j.ygyno.2016.11.019
[Indexed for MEDLINE]

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