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Nutr Res. 2016 Dec;36(12):1392-1401. doi: 10.1016/j.nutres.2016.11.007. Epub 2016 Nov 17.

Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial.

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Institute of Food and Nutrition Development, Ministry of Agriculture, Haidian, Beijing 100081, China.
Peking Union Medical College Hospital, Dongcheng, Beijing 100730, China.
Pinggu Hospital of Traditional Chinese Medicine, Pinggu, Beijing 101200, China.
College of Food Science and Nutritional Engineering, China Agricultural University, Haidian, Beijing 100083, China. Electronic address:


Tartary buckwheat (TB) is rich in protein, dietary fiber, and flavonoids and has been reported to affect type 2 diabetes mellitus (T2DM) in animal experiments, but limited information on the benefit of TB as a whole food in T2DM patients is available. Thus, we tested the hypothesis that a daily replacement of a portion of the staple food with TB will improve risk factors of T2DM, including fasting glucose, insulin resistance, and lipid profile. In a parallel, randomized, open-label, controlled trial, 165 T2DM patients were randomly assigned to a control diet group (DC group; systematic diet plans and intensive nutritional education) or a TB intervention group (TB group; daily replacement of a portion of staple food with TB food). Blood samples and diet information were collected at baseline and after 4 weeks of intervention. The TB group decreased fasting insulin (2.46-2.39 Ln mU/L), total cholesterol (5.08-4.79 mmol/L), and low-density lipoprotein cholesterol (3.00-2.80 mmol/L) compared with the DC group at 4 weeks (P<.05). No significant differences in blood glucose or glycated hemoglobin levels were noted between the TB and DC groups. In addition, subgroup analyses based on daily TB intake dose showed a reduction in insulin, total cholesterol, and low-density lipoprotein cholesterol, but also insulin resistance was observed when TB intake dose was greater than 110 g/d. These results support the hypothesis that TB may improve insulin resistance and lipid profile in T2DM patients.


Dietary intervention; Insulin resistance; Lipid; Tartary buckwheat; Type 2 diabetes mellitus

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