Format

Send to

Choose Destination
J Psychiatr Res. 2017 Mar;86:58-65. doi: 10.1016/j.jpsychires.2016.11.010. Epub 2016 Nov 19.

Childhood adversity impacts on brain subcortical structures relevant to depression.

Author information

1
Department of Psychiatry and Psychotherapy, Otto von Guericke University of Magdeburg, Germany; Department of Psychiatry, University of Dublin, Trinity College, Dublin, Ireland. Electronic address: Thomas.Frodl@med.ovgu.de.
2
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany.
3
Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
4
Department of Psychiatry and Psychotherapy, Otto von Guericke University of Magdeburg, Germany; Department of Psychiatry, University of Dublin, Trinity College, Dublin, Ireland.
5
Department of Psychiatry and Psychotherapy, Otto von Guericke University of Magdeburg, Germany.
6
Department of Psychiatry and Mental Health, University of Cape Town, South Africa.
7
Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
8
German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, Germany.
9
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
10
Imaging Genetics Center, Department of Neurology, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
11
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany; Sociology of Physical Activity and Health, Department of Health Sciences, University of Potsdam, Germany.
12
Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Germany.
13
Institute for Community Medicine, University Medicine Greifswald, Germany.
14
Brain and Mind Centre, University of Sydney, Camperdown, Australia; Sunshine Coast Mind and Neuroscience - Thompson Institute, University of The Sunshine Coast, QLD, Australia.
15
Brain and Mind Centre, University of Sydney, Camperdown, Australia.
16
Department of Psychiatry, University of Regensburg, Regensburg, Germany.
17
Department of Psychiatry and Psychotherapy, Otto von Guericke University of Magdeburg, Germany; Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
18
Charité Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Division of Mind and Brain Research, Berlin, Germany.
19
Department of General Psychiatry, University Hospital Heidelberg, Germany.
20
Department of Psychiatry and Psychotherapy, University of Münster, Germany.
21
Department of Clinical Radiology, University of Münster, Germany.
22
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany; Psychiatric University Clinic, Basel, Switzerland.
23
Department of Psychiatry and Psychotherapy, Agaplesion Diakoniklinikum, Rotenburg, Germany; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.
24
Center for Integrative Psychiatry, University of Lübeck, Lübeck, Germany.
25
Discipline of Psychiatry, School of Medicine, University of Adelaide, SA 5005 Adelaide, Australia.
26
Department of Psychiatry, Leiden Institute for Brain and Cognition and Leiden Center for Translational Neuroscience, Leiden, The Netherlands.
27
Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
28
Department of Psychiatry and Psychotherapy, University of Münster, Germany; Department of Psychiatry, University of Marburg, Germany.
29
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, Germany; Helios Hospital Stralsund, Germany.

Abstract

Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression.

KEYWORDS:

Caudate; Childhood adversity; Depression; ENIGMA; Hippocampus; MRI

PMID:
27918926
PMCID:
PMC5564511
DOI:
10.1016/j.jpsychires.2016.11.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center