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Nat Neurosci. 2017 Jan;20(1):20-23. doi: 10.1038/nn.4452. Epub 2016 Dec 5.

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning.

Author information

1
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
2
Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India.

Abstract

Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.

PMID:
27918532
PMCID:
PMC5191939
DOI:
10.1038/nn.4452
[Indexed for MEDLINE]
Free PMC Article

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