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Nat Neurosci. 2017 Feb;20(2):167-169. doi: 10.1038/nn.4451. Epub 2016 Dec 5.

HSD2 neurons in the hindbrain drive sodium appetite.

Author information

1
Department of Biochemistry, University of Washington, Seattle, Washington, USA.
2
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.

Abstract

Sodium-depleted animals develop an appetite for aversive concentrations of sodium. Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11β-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger. These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.

PMID:
27918529
DOI:
10.1038/nn.4451
[Indexed for MEDLINE]

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