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Nutrients. 2016 Dec 2;8(12). pii: E783.

Potential of Lactobacillus plantarum CCFM639 in Protecting against Aluminum Toxicity Mediated by Intestinal Barrier Function and Oxidative Stress.

Yu L1,2, Zhai Q3,4, Tian F5,6, Liu X7, Wang G8, Zhao J9, Zhang H10,11, Narbad A12,13,14, Chen W15,16,17.

Author information

1
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. edyulei@126.com.
2
UK-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, UK. edyulei@126.com.
3
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. zhaiqixiao@sina.com.
4
UK-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, UK. zhaiqixiao@sina.com.
5
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. fwtian@jiangnan.edu.cn.
6
UK-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, UK. fwtian@jiangnan.edu.cn.
7
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. liuxm@jiangnan.edu.cn.
8
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. wanggang@jiangnan.edu.cn.
9
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. jxzhao@jiangnan.edu.cn.
10
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. zhanghao@jiangnan.edu.cn.
11
UK-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, UK. zhanghao@jiangnan.edu.cn.
12
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. arjan.narbad@ifr.ac.uk.
13
UK-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, UK. arjan.narbad@ifr.ac.uk.
14
Gut Health and Food Safety Programme, Institute of Food Research, Norwich NR4 7UA, UK. arjan.narbad@ifr.ac.uk.
15
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. chenwei66@jiangnan.edu.cn.
16
UK-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, UK. chenwei66@jiangnan.edu.cn.
17
Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology & Business University, Beijing 100048, China. chenwei66@jiangnan.edu.cn.

Abstract

Aluminum (Al) is a ubiquitous metal that can seriously harm the health of animals and humans. In our previous study, we demonstrated that Lactobacillus plantarum CCFM639 can decrease Al burden in the tissues of mice by inhibiting intestinal Al absorption. The main aim of the present research was to investigate whether the protection by the strain is also associated with enhancement of the intestinal barrier, alleviation of oxidative stress and modulation of the inflammatory response. In an in vitro cell model, two protection modes (intervention and therapy) were examined and the results indicated that L. plantarum CCFM639 alleviated Al-induced cytotoxicity. In a mouse model, L. plantarum CCFM639 treatment was found to significantly alleviate oxidative stress in the intestinal tract, regulate the function of the intestinal mucosal immune system, restore the integrity of tight junction proteins and maintain intestinal permeability. These results suggest that in addition to Al sequestration, L. plantarum CCFM639 can also inhibit Al absorption by protecting the intestinal barrier, alleviating Al-induced oxidative stress and inflammatory response. Therefore, L. plantarum CCFM639 has the potential to be a dietary supplement ingredient that provides protection against Al-induced gut injury.

KEYWORDS:

Lactobacillus plantarum; aluminum; gut health; lactic acid bacteria; probiotic; protection

PMID:
27918411
PMCID:
PMC5188438
DOI:
10.3390/nu8120783
[Indexed for MEDLINE]
Free PMC Article

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