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Front Behav Neurosci. 2016 Nov 21;10:225. eCollection 2016.

Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations.

Author information

1
Institut national de la Recherche Agronomique (INRA), Nutrition and Integrative Neurobiology, UMR 1286Bordeaux, France; Université de BordeauxBordeaux, France.
2
Institut national de la Recherche Agronomique (INRA), Nutrition and Integrative Neurobiology, UMR 1286Bordeaux, France; Université de BordeauxBordeaux, France; Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287Bordeaux, France.
3
Université de BordeauxBordeaux, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1215 Neuro Centre MagendieBordeaux, France.
4
Biological and Health Sciences Division, Campus Lerma, Metropolitan Autonomous University (UAM) Lerma, Mexico.
5
Université de BordeauxBordeaux, France; Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287Bordeaux, France.

Abstract

In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al., 2012, 2014, 2015). Here, we assessed whether the effects of adolescent HF consumption on brain function are permanent or reversible. After adolescent exposure to HF, switching to a standard control diet restored levels of hippocampal neurogenesis and normalized enhanced HPA axis reactivity, amygdala activity and avoidance memory. Therefore, while the adolescent period is highly vulnerable to the deleterious effects of diet-induced obesity, adult exposure to a standard diet appears sufficient to reverse alterations of brain function.

KEYWORDS:

adolescence; amygdala; hippocampus; learning; neurogenesis; obesity; rat

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