Format

Send to

Choose Destination
Front Mol Neurosci. 2016 Nov 21;9:128. eCollection 2016.

Role of microRNAs in the Regulation of α-Synuclein Expression: A Systematic Review.

Author information

1
Department of Neurogenetics, Kolling Institute, The Royal North Shore Hospital, Northern Sydney Local Health DistrictSt. Leonards, NSW, Australia; Northern Clinical School, Sydney Medical School, University of SydneySydney, NSW, Australia.
2
Neurodegenerative Disease Laboratory, Vall d'Hebron Research Institute and Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) Barcelona, Spain.

Abstract

Growing evidence suggests that increased levels of α-synuclein might contribute to the pathogenesis of Parkinson's disease (PD) and therefore, it is crucial to understand the mechanisms underlying α-synuclein expression. Recently, microRNAs (miRNAs) have emerged as key regulators of gene expression involved in several diseases such as PD and other neurodegenerative disorders. A systematic literature search was performed here to identify microRNAs that directly or indirectly impact in α-synuclein expression/accumulation and describe its mechanism of action. A total of 27 studies were incorporated in the review article showing evidences that six microRNAs directly bind and regulate α-synuclein expression while several miRNAs impact on α-synuclein expression indirectly by targeting other genes. In turn, α-synuclein overexpression also impacts miRNAs expression, indicating the complex network between miRNAs and α-synuclein. From the current knowledge on the central role of α-synuclein in PD pathogenesis/progression, miRNAs are likely to play a crucial role at different stages of PD and might potentially be considered as new PD therapeutic approaches.

KEYWORDS:

Parkinson’s disease; alpha-synuclein; gene expression; gene regulation; miRNA; microRNA; α-synuclein

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center