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J Heart Lung Transplant. 2016 Dec;35(12):1385-1398. doi: 10.1016/j.healun.2016.10.005. Epub 2016 Oct 17.

State of the Art: Bridging to lung transplantation using artificial organ support technologies.

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Center for Advanced Heart Failure and Department of Cardiothoracic/Vascular Surgery, University of Texas-Houston and Memorial Hermann-Texas Medical Center, Houston, Texas. Electronic address:
Department of Respiratory Medicine, Hannover Medical School, and German Center for Lung Research (DZL), Hannover, Germany.


Lung transplantation increasingly is being performed in recipients of higher risk and acuity. A subset of these patients has severely abnormal gas exchange and/or right ventricular dysfunction, such that artificial organ support strategies are required to bridge patients to lung transplantation. We review the rationales and currently used and potential strategies for bridging to lung transplantation and characterize bridging outcomes. Based on physiologic reasoning and a study of the existing literature, we provide a working strategy for bridging to lung transplantation.


artificial organ support; end-stage lung disease; extracorporeal membrane oxygenation; lung transplantation; mechanical ventilation

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