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J Am Med Dir Assoc. 2017 Apr 1;18(4):312-319. doi: 10.1016/j.jamda.2016.10.001. Epub 2016 Nov 30.

Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study.

Collaborators (157)

Gill T, Fragoso C, Fielding R, Hauser ME, Pahor M, Guralnik JM, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu CJ, Miller ME, Espeland MA, Ambrosius WT, Applegate W, Beavers DP, Byington RP, Cook D, Furberg CD, Harvin LN, Henkin L, Hepler MJ, Hsu FC, Lovato L, Roberson W, Rushing J, Rushing S, Stowe CL, Walkup MP, Hire D, Rejeski WJ, Katula JA, Brubaker PH, Mihalko SL, Jennings JM, Hadley EC, Romashkan S, Patel KV, Bonds D, McDermott MM, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church TS, Blair SN, Myers VH, Monce R, Britt NE, Harris MN, McGucken AP, Rodarte R, Millet HK, Tudor-Locke C, Butitta BP, Donatto SG, Cocreham SH, King AC, Castro CM, Haskell WL, Stafford RS, Pruitt LA, Berra K, Yank V, Fielding RA, Nelson ME, Folta SC, Phillips EM, Liu CK, McDavitt EC, Reid KF, Kirn DR, Pasha EP, Kim WS, Beard VE, Tsiroyannis EX, Hau C, Manini TM, Pahor M, Anton SD, Nayfield S, Buford TW, Marsiske M, Sandesara BD, Knaggs JD, Lorow MS, Marena WC, Korytov I, Morris HL, Fitch M, Singletary FF, Causer J, Radcliff KA, Newman AB, Studenski SA, Goodpaster BH, Glynn NW, Lopez O, Nadkarni NK, Williams K, Newman MA, Grove G, Bonk JT, Rush J, Kost P, Ives DG, Kritchevsky SB, Marsh AP, Brinkley TE, Demons JS, Sink KM, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill TM, Axtell RS, Kashaf SS, de Rekeneire N, McGloin JM, Wu KC, Shepard DM, Fennelly B, Iannone LP, Mautner R, Barnett TS, Halpin SN, Brennan MJ, Bugaj JA, Zenoni MA, Mignosa BM, Williamson J, Sink KM, Hendrie HC, Rapp SR, Verghese J, Woolard N, Espeland M, Jennings J, Wilson VK, Pepine CJ, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp GL, Flynn GM, Gill TM, Hankinson JL, Vaz Fragoso CA, Groessl EJ, Kaplan RM.

Author information

1
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL; Department of Sciences of Physical Activity, Université du Québec à Montréal, CRIUGM, Montréal, Québec, Canada. Electronic address: aubertin.mylene@gmail.com.
2
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL.
3
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
4
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
5
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
6
Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
7
Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, NC.
8
Department of Kinesiology, Pennsylvania State University, University Park, PA.
9
Department of Internal Medicine, Northwestern Medical Faculty Foundation, Chicago, IL.
10
Institute of Gerontology, University of Michingan, Ann Arbor, MI.
11
Stanford Prevention Research Center, Stanford University, Palo Alto, CA.

Abstract

OBJECTIVE:

The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults.

METHODS:

A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions.

RESULTS:

A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]).

CONCLUSION:

Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.

KEYWORDS:

Muscle strength; aging; metabolic syndrome; obesity

PMID:
27914851
PMCID:
PMC5366275
DOI:
10.1016/j.jamda.2016.10.001
[Indexed for MEDLINE]
Free PMC Article

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