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Br J Ophthalmol. 2017 Jan;101(1):45-50. doi: 10.1136/bjophthalmol-2016-309094. Epub 2016 Dec 2.

Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography.

Author information

1
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.

Abstract

PURPOSE:

To evaluate the morphological structure of ill-defined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA).

METHODS:

A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. En face OCT angiograms were compared with FA.

RESULTS:

Eleven cases of ill-defined CNV on FA were identified from 10 study participants. Mean age of the participants was 74.5±6.8 years. Six cases had late leakage from undetermined source (LLUS) and five had fibrovascular pigment epithelial detachment (FVPED). Combining cross-sectional structural OCT with OCT angiograms, all cases were found to have type 1 CNV that corresponded to occult CNV with FA. In all cases of occult CNV on FA, distinct vascular structures were visible with OCTA in the outer retinal/retinal pigment epithelium slab. The mean CNV vessel area was 2.61±3.65 mm2. The mean CNV vessel area in cases with FVPED was larger than that in cases with LLUS (4.69±4.72 mm2 compared with 0.85±0.90 mm2, Mann-Whitney p value=0.04).

CONCLUSIONS:

Although the sample size is small to draw conclusions and the nature of work is retrospective and descriptive, OCTA has the potential to improve visualisation of ill-defined CNV with dye-based angiography, including occult CNV.

KEYWORDS:

Choroid; Imaging; Neovascularisation

PMID:
27913440
PMCID:
PMC5805390
DOI:
10.1136/bjophthalmol-2016-309094
[Indexed for MEDLINE]
Free PMC Article

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