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Mech Dev. 2017 Apr;144(Pt A):92-101. doi: 10.1016/j.mod.2016.11.003. Epub 2016 Nov 29.

Mechanical forces during muscle development.

Author information

1
Muscle Dynamics Group, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
2
Muscle Dynamics Group, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany; Developmental Biology Institute of Marseille (IBDM), CNRS, UMR 7288, Aix-Marseille Université, Case 907, Parc Scientifique de Luminy, 13288 Marseille, France. Electronic address: frank.schnorrer@univ-amu.fr.

Abstract

Muscles are the major force producing tissue in the human body. While certain muscle types specialize in producing maximum forces, others are very enduring. An extreme example is the heart, which continuously beats for the entire life. Despite being specialized, all body muscles share similar contractile mini-machines called sarcomeres that are organized into regular higher order structures called myofibrils. The major sarcomeric components and their organizational principles are conserved throughout most of the animal kingdom. In this review, we discuss recent progress in the understanding of myofibril and sarcomere development largely obtained from in vivo models. We focus on the role of mechanical forces during muscle and myofibril development and propose a tension driven self-organization mechanism for myofibril formation. We discuss recent technological advances that allow quantification of forces across tissues or molecules in vitro and in vivo. Although their application towards muscle development is still in its infancy, these technologies are likely to provide fundamental new insights into the mechanobiology of muscle and myofibril development in the near future.

KEYWORDS:

Biomechanics; Force; Integrin; Muscle; Myofibrillogenesis; Sarcomere; Self-organization; Tension; Titin

PMID:
27913119
DOI:
10.1016/j.mod.2016.11.003
[Indexed for MEDLINE]
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