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Cell Stem Cell. 2016 Dec 1;19(6):686-689. doi: 10.1016/j.stem.2016.11.009.

Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny.

Author information

1
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
2
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA 02114, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA 02114, USA. Electronic address: jrajagopal@mgh.harvard.edu.

Abstract

Feedback signals from daughter cells to stem cells are well studied and known to provide important feedback cues. Emerging evidence shows that stem cells also send feedforward signals to their progeny. Complex circuits involving both negative and positive feedback and feedforward signals likely contribute to robust tissue maintenance and regeneration.

PMID:
27912089
PMCID:
PMC5677519
DOI:
10.1016/j.stem.2016.11.009
[Indexed for MEDLINE]
Free PMC Article

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