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Biochem Soc Trans. 2016 Oct 15;44(5):1385-1393.

Nucleotide modifications in messenger RNA and their role in development and disease.

Author information

1
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
2
School of Life Science, Faculty of Health and Life Sciences, Coventry University, Coventry CV1 5FB, U.K.

Abstract

Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.

KEYWORDS:

RNA editing; epitranscriptome; mRNA methylation

PMID:
27911721
DOI:
10.1042/BST20160110
[Indexed for MEDLINE]

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