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J Parkinsons Dis. 2017;7(1):159-162. doi: 10.3233/JPD-160925.

Dementia Predictors in Parkinson Disease: A Validation Study.

Author information

1
Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
2
Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.
3
Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
4
Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada.

Abstract

In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.

KEYWORDS:

Dementia; REM sleep behavior disorder; mild cognitive impairment; prediction

PMID:
27911340
DOI:
10.3233/JPD-160925
[Indexed for MEDLINE]

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