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Carbohydr Res. 1989 Jul 1;190(1):1-11.

Enzymic synthesis of oligosaccharides terminating in the tumor-associated sialyl-Lewis-a determinant.

Author information

1
Department of Food Science, University of Alberta, Edmonton, Canada.

Abstract

The isomeric sialyl-Lea-terminating pentasaccharide derivatives, alpha-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-[alpha-L-Fucp-(1 ----4)]-beta- D-GlcpNAc-(1----3)-beta-D-Galp-O(CH2)8COOMe and alpha-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-[alpha-L-Fucp-(1 ----4)]- beta-D-GlcpNAc-(1----6)-beta-D-Galp-O(CH2)8COOMe, have been prepared by the action in sequence of a porcine submaxillary (2----3)-alpha-sialyltransferase and a human-milk (1----3/4)-alpha-fucosyltransferase on the chemically synthesized trisaccharides beta-D-Galp-(1----3)-beta-D-GlcpNAc-(1----3)- and -(1----6)-beta-D-Galp- O(CH2)8COOMe, respectively.

PMID:
2790838
DOI:
10.1016/0008-6215(89)84141-2
[Indexed for MEDLINE]

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