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Nature. 2016 Dec 1;540(7631):51-59. doi: 10.1038/nature20573.

Stem cells and interspecies chimaeras.

Author information

1
Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA.
2
Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, nº 135 Guadalupe 30107, Murcia, Spain.
3
Center for Law and the Biosciences, Stanford Law School, 559 Nathan Abbott Way Stanford, California 94305-8610, USA.
4
The Whitehead Institute for Biomedical Research and Department of Biology, MIT, Cambridge, Massachusetts 02142, USA.
5
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5101, USA.
6
Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
7
Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.
8
Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

Abstract

Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the identification and generation of various kinds of stem cells, have broadened the repertoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding fundamental biology as well as potential clinical applications.

PMID:
27905428
DOI:
10.1038/nature20573
[Indexed for MEDLINE]

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