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Am J Transl Res. 2016 Nov 15;8(11):4705-4715. eCollection 2016.

MicroRNA-206 acts as a tumor suppressor in bladder cancer via targeting YRDC.

Author information

1
Department of Urology, Shanghai Tenth People's Hospital, Tongji University 301 Yanchang Road, Shanghai 200072, China.
2
Department of Urology, Shanghai Tenth People's Hospital, Tongji University301 Yanchang Road, Shanghai 200072, China; Department of First Clinical Medical College, Nanjing Medical UniversityNanjing, Jiangsu, China.

Abstract

Accumulating evidence suggested that microRNA (miRNA) plays important regulatory roles in the initiation and development of various cancers. Previous study showed that microRNA-206 (miR-206) is dysregulated in human bladder cancer tissues, however, the biological function and underlying mechanisms of miR-206 in human bladder cancer remain unknown. In the present study, we aimed to investigate the clinical significance of miR-206 and its target gene YRDC in human bladder cancer, and to determine its effects on oncogenic phenotypes of this disease. Our results showed that miR-206 expression was downregulated significantly in bladder cancer tissues and cell lines compared with adjacent normal bladder tissues and human bladder epithelial immortalized SV-HUC-1 cell line, respectively. Overexpression of miR-206 reduced the expression of YRDC and inhibited bladder cancer cell proliferation, colony formation, migration, invasion and induced cell cycle arrest at G0/G1 phase. In addition, knockdown of YRDC exhibited similar effects with miR-206 overexpression in bladder cancer cells and restoration of YRDC partially reversed the effects of miR-206 in bladder cancer cells. These findings indicated that mir-206 might be a novel target for bladder cancer therapy by targeting YRDC.

KEYWORDS:

YRDC; bladder cancer; miR-206; tumor suppressor

PMID:
27904673
PMCID:
PMC5126315

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