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Mult Scler. 2017 Oct;23(11):1469-1478. doi: 10.1177/1352458516681504. Epub 2016 Dec 7.

Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.

Author information

1
Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
2
Imanova Ltd, Imperial College London, London, UK/Centre for Neuroimaging Sciences, King's College London, London, UK.
3
Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK/manova Ltd, Imperial College London, London, UK.
4
Queen Square Multiple Sclerosis Centre, Institute of Neurology, University College London, London, UK.

Abstract

BACKGROUND:

Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this.

OBJECTIVE:

To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS over a range of brain inflammatory burden.

METHODS:

A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability was assessed by Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC).

RESULTS:

[11C]PBR28 uptake and [ myo-inositol] were not associated. When the whole cohort was stratified by higher [11C]PBR28 inflammatory burden, [ myo-inositol] was positively correlated to [11C]PBR28 uptake (Spearman's ρ = 0.685, p = 0.014). Moderate correlations were found between [11C]PBR28 uptake and both MRS creatine normalised N-acetyl aspartate (NAA) concentration and grey matter volume. MSFC was correlated with grey matter volume (ρ = 0.535, p = 0.009). There were no associations between other imaging or clinical measures.

CONCLUSION:

MRS [ myo-inositol] and PET [11C]PBR28 measure independent inflammatory processes which may be more commonly found together with more severe inflammatory disease. Microglial activation measured by [11C]PBR28 uptake was associated with loss of neuronal integrity and grey matter atrophy.

KEYWORDS:

MRI; Multiple sclerosis; biomarkers; glia

PMID:
27903933
DOI:
10.1177/1352458516681504
[Indexed for MEDLINE]
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