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Diabetes. 2017 Feb;66(2):418-425. doi: 10.2337/db16-0680. Epub 2016 Nov 30.

Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome.

Author information

1
Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
2
Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
3
Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
4
The Metabolomics Innovation Centre, University of Alberta, Edmonton, Alberta, Canada.
5
Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada jason.dyck@ualberta.ca.

Abstract

Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, Moryella, Lachnospiraceae, and Akkermansia and an increased relative abundance of Bacteroides and Parabacteroides Moreover, fecal transplantation from healthy resveratrol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the resveratrol-mediated changes in the gut microbiome may play an important role in the mechanism of action of resveratrol.

PMID:
27903747
DOI:
10.2337/db16-0680
[Indexed for MEDLINE]
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