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Clin Microbiol Rev. 2017 Jan;30(1):277-319.

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.

Author information

1
Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
2
Alberta Provincial Laboratory for Public Health, ProvLab, Edmonton, Alberta, Canada steven.drews@albertahealthservices.ca marchant@ualberta.ca.
3
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
4
Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada steven.drews@albertahealthservices.ca marchant@ualberta.ca.

Abstract

Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children in North America and one of the leading causes of death of infants less than 1 year of age worldwide, second only to malaria. Despite its global impact on human health, there are relatively few therapeutic options available to prevent or treat RSV infection. Paradoxically, there is a very large volume of information that is constantly being refined on RSV replication, the mechanisms of RSV-induced pathology, and community transmission. Compounding the burden of acute RSV infections is the exacerbation of preexisting chronic airway diseases and the chronic sequelae of RSV infection. A mechanistic link is even starting to emerge between asthma and those who suffer severe RSV infection early in childhood. In this article, we discuss developments in the understanding of RSV replication, pathogenesis, diagnostics, and therapeutics. We attempt to reconcile the large body of information on RSV and why after many clinical trials there is still no efficacious RSV vaccine and few therapeutics.

KEYWORDS:

diagnostics; epidemiology; experimental therapeutics; immunization; respiratory syncytial virus; viral pathogenesis

PMID:
27903593
PMCID:
PMC5217795
DOI:
10.1128/CMR.00010-16
[Indexed for MEDLINE]
Free PMC Article

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