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Head Neck. 2017 Mar;39(3):555-563. doi: 10.1002/hed.24642. Epub 2016 Nov 30.

Predictive factors and treatment outcome of laryngeal carcinoma recurrence.

Author information

1
Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
2
Department of Otorhinolaryngology - Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.
3
PEDEGO Research Unit, University of Oulu, Oulu, Finland.
4
Medical Research Center Oulu, Oulu, Finland.

Abstract

BACKGROUND:

Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence.

METHODS:

A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy (n = 316) was analyzed.

RESULTS:

Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment. The World Health Organization (WHO) performance status >0, neck metastasis at presentation, and nonsurgical treatment were independent prognostic factors for recurrence. Patients with local recurrence had a 5-year overall survival (OS) of 53% compared with 5% in patients with regional/distant recurrences. OS for glottic and nonglottic laryngeal SCC recurrence was 45% and 0%, respectively.

CONCLUSION:

The type of treatment affected the risk of recurrence in this retrospective series. Local recurrences carried a chance for successful salvage treatment. Routine follow-up beyond 36 months remains controversial. © 2016 Wiley Periodicals, Inc. Head Neck 39: 555-563, 2017.

KEYWORDS:

laryngeal cancer; prognosis; radiotherapy; recurrence; surgery

PMID:
27902867
DOI:
10.1002/hed.24642
[Indexed for MEDLINE]

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