Format

Send to

Choose Destination
Nucleic Acids Res. 2017 Jan 4;45(D1):D115-D118. doi: 10.1093/nar/gkw1052. Epub 2016 Nov 28.

RAID v2.0: an updated resource of RNA-associated interactions across organisms.

Author information

1
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
2
Department of Pathology, Harbin Medical University, Harbin 150081, China.
3
Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, China.
4
Department of Pathology, Harbin Medical University, Harbin 150081, China lixiaobo@ems.hrbmu.edu.cn.
5
State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, School of Basic Sciences & Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China j-yu@ibms.pumc.edu.cn.
6
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China wangdong@ems.hrbmu.edu.cn.

Abstract

With the development of biotechnologies and computational prediction algorithms, the number of experimental and computational prediction RNA-associated interactions has grown rapidly in recent years. However, diverse RNA-associated interactions are scattered over a wide variety of resources and organisms, whereas a fully comprehensive view of diverse RNA-associated interactions is still not available for any species. Hence, we have updated the RAID database to version 2.0 (RAID v2.0, www.rna-society.org/raid/) by integrating experimental and computational prediction interactions from manually reading literature and other database resources under one common framework. The new developments in RAID v2.0 include (i) over 850-fold RNA-associated interactions, an enhancement compared to the previous version; (ii) numerous resources integrated with experimental or computational prediction evidence for each RNA-associated interaction; (iii) a reliability assessment for each RNA-associated interaction based on an integrative confidence score; and (iv) an increase of species coverage to 60. Consequently, RAID v2.0 recruits more than 5.27 million RNA-associated interactions, including more than 4 million RNA-RNA interactions and more than 1.2 million RNA-protein interactions, referring to nearly 130 000 RNA/protein symbols across 60 species.

PMID:
27899615
PMCID:
PMC5210540
DOI:
10.1093/nar/gkw1052
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center