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Sci Signal. 2016 Nov 29;9(456):c23.

Science Signaling Podcast for 29 November 2016: Pre-B cell receptor signaling in leukemia.

Author information

1
Department of Pathology and the UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA.
2
Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract

This Podcast features an interview with Bridget Wilson, author of a Research Article that appears in the 29 November 2016 issue of Science Signaling, about pre-B cell receptor (pre-BCR) signaling in B cell precursor acute lymphoblastic leukemia (BCP-ALL). Signaling through the pre-BCR, an immature form of the BCR, promotes the survival of B cell progenitors and has been implicated in the pathology of BCP-ALL. Erasmus et al found that pre-BCRs formed transient homomeric complexes that correlated with pro-survival signaling. Preventing homotypic interactions between pre-BCRs sensitized B cells to chemotherapeutic agents, suggesting that interfering with such interactions may improve the efficacy of existing chemotherapies for BCP-ALL.Listen to Podcast.

PMID:
27899524
DOI:
10.1126/scisignal.aal3599
[Indexed for MEDLINE]

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