Format

Send to

Choose Destination
Seizure. 2017 Jan;44:137-142. doi: 10.1016/j.seizure.2016.10.027. Epub 2016 Nov 19.

A prestimulation evaluation protocol for patients with drug resistant epilepsy.

Author information

1
Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address: sofie.carrette@ugent.be.
2
Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

Abstract

Neurostimulation is making its way into the therapeutic armamentarium of the epileptologists, with several invasive neurostimulation modalities available today and several less invasive modalities under investigation. Clinicians will soon face a choice that should not be made randomly. We introduce the concept of a prestimulation evaluation protocol, consisting of a series of rationally chosen investigations that evaluate the presence of biomarkers for response to various neurostimulation therapies. These biomarkers should reflect the susceptibility of the individual's epileptic network to a given neurostimulation technique. This will require elucidation of the specific mechanism(s) of action of the different neurostimulation modalities. This manuscript provides a hypothetical framework that may be more applicable in the near future when pre-clinical research progresses and can be translated into human applications.

KEYWORDS:

Epilepsy; Neurostimulation; Response prediction; Treatment

PMID:
27899261
DOI:
10.1016/j.seizure.2016.10.027
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center