Format

Send to

Choose Destination
Biomarkers. 2017 Nov;22(7):635-642. doi: 10.1080/1354750X.2016.1265003. Epub 2016 Dec 8.

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

Author information

1
a Department of Molecular and Clinical Pharmacology , Institute of Translational Medicine University of Liverpool , Liverpool , United Kingdom.
2
b Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health UK , University of Liverpool , Liverpool , United Kingdom.
3
c NIHR Health Protection Research Unit in Emerging and Zoonotic Infections , University of Liverpool , Liverpool , United Kingdom.
4
e Department of Infectious Diseases, Leeds Teaching Hospitals NHS Trust, West Yorkshire , Leeds, United Kingdom.
5
d The Walton Centre NHS Foundation Trust , Liverpool , United Kingdom.

Abstract

AIMS:

To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, high-mobility group box 1 (HMGB1), in different neurological conditions.

METHODS:

HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension [IIH], 18 neurological infection/inflammation [NII] and 10 Rasmussen's encephalitis [RE]).

RESULTS:

Mean serum (± SD) HMGB1 levels were 1.43 ± 0.54, 25.28 ± 27.9 and 1.89 ± 1.49 ng/ml for the patients with IIH, NII and RE, respectively. Corresponding mean (± SD) CSF levels were 0.35 ± 0.22, 4.48 ± 6.56 and 2.24 ± 2.35 ng/ml. Both CSF and serum HMGB1 was elevated in NII. Elevated CSF HMGB1 was demonstrated in RE. There was no direct correlation between CSF and serum levels of HMGB1.

CONCLUSION:

Serum HMGB1 cannot be used as a surrogate measure for CSF levels. CSF HMGB1 was elevated in NII and RE, its role as a prognostic/stratification biomarker needs further study.

KEYWORDS:

High-mobility group box 1 (HMGB1); biomarker; cerebrospinal fluid

PMID:
27899037
DOI:
10.1080/1354750X.2016.1265003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center