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Sensors (Basel). 2016 Nov 25;16(12). pii: E1992.

Optical Microbubble Resonators with High Refractive Index Inner Coating for Bio-Sensing Applications: An Analytical Approach.

Author information

1
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. a.barucci@ifac.cnr.it.
2
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. s.berneschi@ifac.cnr.it.
3
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. a.giannetti@ifac.cnr.it.
4
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. f.baldini@ifac.cnr.it.
5
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. a.cosci@ifac.cnr.it.
6
Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. a.cosci@ifac.cnr.it.
7
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. s.pelli@ifac.cnr.it.
8
Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. s.pelli@ifac.cnr.it.
9
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. d.farnesi@ifac.cnr.it.
10
Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. d.farnesi@ifac.cnr.it.
11
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. giancarlo.righini@centrofermi.it.
12
Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. giancarlo.righini@centrofermi.it.
13
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. s.soria@ifac.cnr.it.
14
Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. g.nunziconti@ifac.cnr.it.

Abstract

The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the design of an optical microbubble resonator (OMBR)-based biosensor. In order to enhance the OMBR sensing performance, we consider a polymeric layer of high refractive index as an inner coating for the OMBR. The effect of this layer and other optical/geometrical parameters on the mode field distribution, sensitivity and LoD of the OMBR is assessed and discussed, both for transverse electric (TE) and transverse magnetic (TM) polarization. The obtained results do provide physical insights for the development of OMBR-based biosensor.

KEYWORDS:

high refractive index polymer; optical microbubble resonator; optical modeling; whispering gallery mode resonators

PMID:
27898015
PMCID:
PMC5190973
DOI:
10.3390/s16121992
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

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