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Mar Drugs. 2016 Nov 25;14(12). pii: E217.

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂.

Author information

1
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. liuhj8@mail2.sysu.edu.cn.
2
School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. liuhj8@mail2.sysu.edu.cn.
3
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. chensh65@mail2.sysu.edu.cn.
4
School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. liuwy79@yahoo.com.
5
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. liuyayue@mail2.sysu.edu.cn.
6
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. huangxishan13@foxmail.com.
7
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesshzhg@mail.sysu.edu.cn.
8
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. cesshzhg@mail.sysu.edu.cn.

Abstract

Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY₂ isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC50 values ranging from 5.9 to 9.3 μg/mL.

KEYWORDS:

Penicillium sp.; immunosuppressive activity; marine fungus; polyketides

PMID:
27897975
PMCID:
PMC5192454
DOI:
10.3390/md14120217
[Indexed for MEDLINE]
Free PMC Article

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