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Nat Cell Biol. 2016 Nov 29;18(12):1267-1268. doi: 10.1038/ncb3449.

Remodelling germ cells by intercellular cannibalism.

Author information

1
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Abstract

Work from the early 1980s reported strange lobes protruding from Caenorhabditis elegans germ cell precursors. However, the fate and potential significance of these lobes remained unexplored for decades. Now, neighbouring endodermal cells are shown to sever and digest these lobes, in an unexpected process of 'intercellular cannibalism', which could play an important part in regulating primordial germ cells.

PMID:
27897161
PMCID:
PMC5480285
DOI:
10.1038/ncb3449
[Indexed for MEDLINE]
Free PMC Article

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