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Data Brief. 2016 Nov 5;9:931-939. eCollection 2016 Dec.

Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy.

Author information

1
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Aspirnaut, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
2
Aspirnaut, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
3
Valencia University Medical School, Valencia, Spain; FibroStatin, SL, Valencia, Spain.
4
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Center for Matrix Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
5
Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
6
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Valencia University Medical School, Valencia, Spain; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Center for Matrix Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, United States; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Vanderbilt Ingram Cancer Center, Nashville, Tennessee, United States; Vanderbilt Institute of Chemical Biology, Nashville, Tennessee, United States.

Abstract

Basement membranes (BMs) are specialized extracellular scaffolds that provide architecture and modulate cell behaviors in tissues, such as fat, muscle, endothelium, endometrium, and decidua. Properties of BMs are maintained in homeostasis for most adult tissues. However, BM ultrastructure, composition, and localization are rapidly altered in select uterine tissues that are reprogrammed during pregnancy to enable early maternal-embryo interactions. Here, our data exhibit both static and dynamic BMs that were tracked in mouse uterine tissues during pre-, peri-, and postimplantation periods of pregnancy. The data exhibit spatial-temporal patterns of BM property regulation that coincide with the progression of adapted physiology. Further interpretation and discussion of these data in this article are described in the associated research article titled, "Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming" (C.R. Jones-Paris, S. Paria, T. Berg, J. Saus, G. Bhave, B.C. Paria, B.G. Hudson, 2016) [1].

KEYWORDS:

Basement membrane

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