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Biomed Opt Express. 2016 Oct 18;7(11):4621-4635. eCollection 2016 Nov 1.

Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics.

Author information

1
School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada.
2
School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada; Department of Electrical and Computer Engineering, Dalhousie University, 1459 Oxford St, Halifax NS, B3H4R2, Canada.
3
School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada; Department of Surgery, Dalhousie University, 1276 South Park St, Halifax NS, B3H2Y9, Canada.

Abstract

We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging. All measurements were performed non-invasively through the intact tympanic membrane demonstrating that the technology is readily translatable to the clinic.

KEYWORDS:

(170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (170.4940) Otolaryngology

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