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Blood. 2017 Jan 26;129(4):424-447. doi: 10.1182/blood-2016-08-733196. Epub 2016 Nov 28.

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.

Author information

1
Department of Internal Medicine III, University of Ulm, Ulm, Germany.
2
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
3
Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
4
Department of Biomedicine and Prevention, Università di Roma "Tor Vergata," Rome, Italy.
5
Department of Hematology/Oncology, University of Münster, Münster, Germany.
6
Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
7
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
8
Service d'Hématologie, Hôpital Saint-Louis, Paris, France.
9
Department of Medicine, University of Chicago, Chicago, IL.
10
Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
11
National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
12
Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany.
13
Department of Haematology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands.
14
Department of Hematology, University Hospital La Fe, University of Valencia, Valencia, Spain.
15
Hematology Department, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain.
16
Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
17
Department of Clinical Hematology, The Alfred Hospital, Melbourne, Australia.
18
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia.
19
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and.
20
The Ohio State University Comprehensive Cancer Center, Columbus, OH.

Abstract

The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.

PMID:
27895058
PMCID:
PMC5291965
DOI:
10.1182/blood-2016-08-733196
[Indexed for MEDLINE]
Free PMC Article

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