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Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e02229-16. doi: 10.1128/AAC.02229-16. Print 2017 Feb.

IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage.

Zhao F1,2, Feng Y1,2, Lü X1,2, McNally A3, Zong Z4,2,5.

Author information

1
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
2
Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
3
Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
4
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China zongzhiy@scu.edu.cn.
5
Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China.

Abstract

A Klebsiella pneumoniae strain of sequence type 313 (ST313) recovered from hospital sewage was found carrying the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP-type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to spread beyond the Enterobacteriaceae family.

KEYWORDS:

Klebsiella pneumoniae; colistin resistance; mcr-1; sewage

PMID:
27895009
PMCID:
PMC5278755
DOI:
10.1128/AAC.02229-16
[Indexed for MEDLINE]
Free PMC Article

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