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Trends Microbiol. 2017 Mar;25(3):192-204. doi: 10.1016/j.tim.2016.11.004. Epub 2016 Nov 25.

The Enigmatic Esx Proteins: Looking Beyond Mycobacteria.

Author information

1
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK. Electronic address: m.unnikrishnan@warwick.ac.uk.
2
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
3
Division of Molecular Microbiology, University of Dundee, Dundee, UK.

Abstract

Bacteria export proteins across membranes using a range of transport machineries. Type VII secretion systems (T7SSs), originally described in mycobacteria, are now known to be widespread across diverse bacterial phyla. Recent studies have characterized secretion components and mechanisms of type VII secretion in pathogenic and environmental bacteria. A variety of functions have been attributed to T7SS substrates, including interactions with eukaryotes and with other bacteria. Here, we evaluate the growing body of knowledge on T7SSs, with focus on the nonmycobacterial systems, reviewing their phylogenetic distribution, structure and function in diverse settings.

KEYWORDS:

Esx; WXG100; toxin–antitoxin; type VII secretion

PMID:
27894646
DOI:
10.1016/j.tim.2016.11.004
[Indexed for MEDLINE]

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