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Nat Methods. 2017 Jan;14(1):61-64. doi: 10.1038/nmeth.4083. Epub 2016 Nov 28.

A scored human protein-protein interaction network to catalyze genomic interpretation.

Author information

1
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
2
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
3
Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
4
Intomics A/S, Lyngby, Denmark.
5
Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
6
Harvard Medical School, Boston, Massachusetts, USA.
7
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
8
Institute for Biological Psychiatry, Mental Health Center Sct. Hans, University of Copenhagen, Roskilde, Denmark.

Abstract

Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.

PMID:
27892958
PMCID:
PMC5839635
DOI:
10.1038/nmeth.4083
[Indexed for MEDLINE]
Free PMC Article

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