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Expert Opin Drug Deliv. 2017 Feb;14(2):155-164. doi: 10.1080/17425247.2017.1266330. Epub 2016 Dec 7.

Incorporation of chemotherapeutic agent and photosensitizer in a low temperature-sensitive liposome for effective chemo-hyperthermic anticancer activity.

Author information

1
a College of Pharmacy , Yeungnam University , Gyeongsan , Republic of Korea.
2
b School of Pharmacy , SungKyunKwan University , Jangan-gu , Suwon , South Korea.
3
c College of Pharmacy , Institute of Pharmaceutical Science and Technology, Hanyang University , Sangnok-gu , Ansan , Republic of Korea.

Abstract

OBJECTIVES:

In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment.

METHODS:

Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity.

RESULTS:

The particle size of LTSL/DI was 130.8 ± 2.3 nm, and its drug release profile was pH- and temperature-dependent, which are effective for tumor targeting. The in vitro anticancer activity of LTSL/DI was significantly enhanced compared with free DOC in SCC-7 and MCF-7 cell lines. Interestingly, near-infrared laser irradiation after the treatment resulted in better anticancer activity than in the non-irradiated condition. The in vivo tumor regression effect of LTSL/DI in combination with NIR irradiation was much greater compared with the control group in SCC-7 tumor-bearing mice. After intratumoral injection of LTSL/DI, local heat induced by NIR irradiation and the localized docetaxel burst release could completely ablate the tumor, and inhibit its recurrence.

CONCLUSIONS:

These results suggest LTSL/DI formulation as a potential therapeutic strategy with effectively localized anti-tumor activity and low risk of side effect to non-target organs.

KEYWORDS:

Docetaxel; hyperthermia; indocyanine green; low temperature-sensitive liposome; near-infrared irradiation

PMID:
27892715
DOI:
10.1080/17425247.2017.1266330
[Indexed for MEDLINE]

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