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Mol Biosyst. 2016 Dec 20;13(1):42-55.

Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer.

Author information

1
Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org and Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.
2
Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org.
3
Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.
4
Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org and Departments of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Abstract

Understanding the complexity of cancer biology requires extensive information about the cancer proteome over the course of the disease. The recent advances in mass spectrometry-based proteomics technologies have led to the accumulation of an incredible amount of such proteomic information. This information allows us to identify protein signatures or protein biomarkers, which can be used to improve cancer diagnosis, prognosis and treatment. For example, mass spectrometry-based proteomics has been used in breast cancer research for over two decades to elucidate protein function. Breast cancer is a heterogeneous group of diseases with distinct molecular features that are reflected in tumour characteristics and clinical outcomes. Compared with all other subtypes of breast cancer, triple-negative breast cancer is perhaps the most distinct in nature and heterogeneity. In this review, we provide an introductory overview of the application of advanced proteomic technologies to triple-negative breast cancer research.

PMID:
27891540
PMCID:
PMC5173390
DOI:
10.1039/c6mb00639f
[Indexed for MEDLINE]
Free PMC Article

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