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Drug Discov Today. 2017 Feb;22(2):234-248. doi: 10.1016/j.drudis.2016.10.017. Epub 2016 Nov 23.

The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts.

Author information

1
Center of Proteomic and Biochemical Analysis, Post-Graduation in Genomic Sciences and Biotechnology Universidade Católica de Brasília UCB, SGAN 916, Modulo B, Bloco C, 70.790-160 Brasilia, DF, Brazil; Genomic Sciences and Biotechnology Program - Universidade Católica de Brasília UCB, SGAN 916, Modulo B, Bloco C, 70.790-160 Brasilia, DF, Brazil.
2
Center of Proteomic and Biochemical Analysis, Post-Graduation in Genomic Sciences and Biotechnology Universidade Católica de Brasília UCB, SGAN 916, Modulo B, Bloco C, 70.790-160 Brasilia, DF, Brazil.
3
Center of Proteomic and Biochemical Analysis, Post-Graduation in Genomic Sciences and Biotechnology Universidade Católica de Brasília UCB, SGAN 916, Modulo B, Bloco C, 70.790-160 Brasilia, DF, Brazil; Universidade Ceuma, Rua Josué Montello, 1, 65060-645 São Luís, MA, Brazil.
4
Synthetic Biology Group, MIT Synthetic Biology Center, Massachusetts Institute of Technology, 02139 Cambridge, MA, USA; Research Laboratory of Electronics, Massachusetts Institute of Technology, 02139 Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, 02139 Cambridge, MA, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 02142 Cambridge, MA, USA; Broad Institute of MIT and Harvard, 02142 Cambridge, MA, USA; Harvard Biophysics Program, Harvard University, 02115 Boston, MA, USA.
5
Genomic Sciences and Biotechnology Program - Universidade Católica de Brasília UCB, SGAN 916, Modulo B, Bloco C, 70.790-160 Brasilia, DF, Brazil. Electronic address: fcosta@genomicenterprise.com.
6
Center of Proteomic and Biochemical Analysis, Post-Graduation in Genomic Sciences and Biotechnology Universidade Católica de Brasília UCB, SGAN 916, Modulo B, Bloco C, 70.790-160 Brasilia, DF, Brazil; Genomic Sciences and Biotechnology Program - Universidade Católica de Brasília UCB, SGAN 916, Modulo B, Bloco C, 70.790-160 Brasilia, DF, Brazil; S-Inova Biotech, Post-Graduation in Biotechnology, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil.

Abstract

Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial activity against a range of pathogenic viruses, bacteria, and fungi. However, the discovery and development of new antibacterial drugs is a crucial step to overcome the great challenge posed by the emergence of antibiotic resistance. In this review, we outline recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design. In addition, we describe recent progress made to overcome some of the major limitations that have hindered peptide biosynthesis.

PMID:
27890668
DOI:
10.1016/j.drudis.2016.10.017
[Indexed for MEDLINE]

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