Format

Send to

Choose Destination
See comment in PubMed Commons below
Epidemiol Infect. 2017 Mar;145(4):642-646. doi: 10.1017/S0950268816002648. Epub 2016 Nov 28.

IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis.

Author information

1
Aliança INFANT Argentina-Brasil.

Abstract

Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) genetic variants are associated with the severity of AB. A group of Brazilian infants hospitalized with AB and a control group (infants with no or mild AB, without hospitalization) were genotyped for four IL-8/IL-17 variations. For replication, we studied an Argentinean population sample of infants with mild and severe AB. IL-8 polymorphism (rs 2227543) and IL-17 (rs2275913) variants showed significant associations with the severity of AB. The effect of the IL-8 variation could be replicated in the Argentinean sample. This finding suggests that IL-8 variations may influence the severity of AB in young infants. Further genetic association studies in low- or middle-income populations are necessary with the aim of expanding knowledge in this area.

KEYWORDS:

Bronchiolitis; interleukin-8; polymorphism; severity; wheezing

PMID:
27890033
DOI:
10.1017/S0950268816002648
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Cambridge University Press
    Loading ...
    Support Center