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J Neurovirol. 2017 Apr;23(2):239-249. doi: 10.1007/s13365-016-0496-6. Epub 2016 Nov 26.

Association of midlife smoking status with change in processing speed and mental flexibility among HIV-seropositive and HIV-seronegative older men: the Multicenter AIDS Cohort Study.

Author information

1
Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, PO Box 100231, Gainesville, FL, 32610, USA. Wajiha.akhtar@dc.gov.
2
Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, PO Box 100231, Gainesville, FL, 32610, USA.
3
David Geffen School of Medicine, Departments of Family Medicine and Psychiatry, University of California, Los Angeles, CA, USA.
4
Semel Institute for Neuroscience, University of California, Los Angeles, CA, USA.
5
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
6
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
7
Department of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
8
Departments of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
9
Malcom Randall VA Medical Center, Gainesville, FL, USA.
10
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
11
Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC, USA.

Abstract

Smoking is a potential risk factor for age-related cognitive decline. To date, no study has examined the association between smoking and cognitive decline in men living with human immunodeficiency virus (HIV). The aim of this present study is to examine whether smoking status and severity in midlife is associated with a rate of decline in cognitive processing speed among older HIV-seropositive and HIV-seronegative men who have sex with men. Data from 591 older HIV-seropositive and HIV-seronegative men who have sex with men from the Multicenter AIDS Cohort Study were examined. All participants had information on smoking history collected before age 50 years and at least 5 years of follow-up after age 50. Smoking history was categorized as never smoker, former smoker, and current smoker and cumulative pack years was calculated. The raw scores of three neuropsychological tests (Trail Making A, Trail Making B, and Symbol Digit Modalities tests) were log transformed (Trail Making A and B) and used in linear mixed models to determine associations between smoking history and at least subsequent 5-year decline in cognitive processing speed. There were no significant differences in the rates of neurological decline among never smokers, former smokers, and current smokers. Findings were similar among HIV-seropositive participants. However, an increase of 5 pack-years was statistically significantly associated with a greater rate of decline in the Trail Making Test B score and Composite Score (β -0.0250 [95% CI, -0.0095 to -0.0006] and -0.0077 [95% CI, -0.0153 to -0.0002], respectively). We found no significant association between smoking treated as a categorical variable (never smoked, former smoker, or current smoker) and a small change in every increase of 5 pack-years on measures of psychomotor speed and cognitive flexibility. To optimize healthy aging, interventions for smoking cessation should be tailored to men who have sex with men.

KEYWORDS:

HIV; Neurocognition; Neuropsychological test; Smoking

PMID:
27889886
PMCID:
PMC5663220
DOI:
10.1007/s13365-016-0496-6
[Indexed for MEDLINE]
Free PMC Article

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