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Otolaryngol Clin North Am. 2017 Feb;50(1):29-47. doi: 10.1016/j.otc.2016.08.004.

Bacterial Pathogens and the Microbiome.

Author information

1
University of Colorado School of Medicine, 13001 East 17th Place, Aurora, CO 80045, USA.
2
Department of Otolaryngology, Head and Neck Surgery, University of Colorado, 12631 East 17th Avenue, B205, Aurora, CO 80045, USA. Electronic address: Vijay.Ramakrishnan@UCDenver.edu.

Abstract

Bacterial pathogens and microbiome alterations can contribute to the initiation and propagation of mucosal inflammation in chronic rhinosinusitis (CRS). In this article, the authors review the clinical and research implications of key pathogens, discuss the role of the microbiome, and connect bacteria to mechanisms of mucosal immunity relevant in CRS.

KEYWORDS:

Bacteria; Chronic rhinosinusitis; Culture-independent microbiology; Microbiome; Sinusitis

PMID:
27888914
PMCID:
PMC5127453
DOI:
10.1016/j.otc.2016.08.004
[Indexed for MEDLINE]
Free PMC Article

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