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Int J Biol Macromol. 2017 Feb;95:363-375. doi: 10.1016/j.ijbiomac.2016.11.068. Epub 2016 Nov 22.

Indole-3-acetic acid/diol based pH-sensitive biological macromolecule for antibacterial, antifungal and antioxidant applications.

G C1, D S F2, S S3, M S4, S G5.

Author information

1
Department of Chemistry, Periyar University, Salem 636011, Tamilnadu, India; Department of Chemistry, Bangalore College of Engineering and Technology, Chandapura, Bangalore 560081, India. Electronic address: chitramuralikrishnan@gmail.com.
2
Department of Chemistry, C. Abdul Hakeem College of Engineering and Technology, Melvisharam 632509, Tamilnadu, India. Electronic address: loyolafrank@yahoo.co.in.
3
Department of Chemistry, C. Abdul Hakeem College of Engineering and Technology, Melvisharam 632509, Tamilnadu, India. Electronic address: srsudarsan29@gmail.com.
4
Research and Development Centre, Bharathiar University, Coimbatore 641046, India. Electronic address: msakthi81986@gmail.com.
5
PG & Research Department of Chemistry, Muthurangam Government Arts College, Vellore 632002, Tamilnadu, India. Electronic address: sai_gugan@yahoo.com.

Abstract

Indole-3-acetic acid (IAA)/diol based pH-sensitive biopolymeric hydrogels with tunable biological properties (cytotoxicity, anti-oxidant and anti-fungal) have been synthesized via condensation polymerization. The present study focused on the synthesis of heterocyclic hydrogel using citric acid (CA), indole-3-acetic acid (IAA) and diethylene glycol (DEG) by condensation polymerization. The hydrogels revealed a pH-sensitive swelling behaviour, with increased swelling in acidic media, then turns to decreased the swelling in the basic media. The hydrogel samples were tested for antifungal activity against Aspergillus fumigates, Rhizopusoryzae and Candida albicans at different concentrations using ketoconazole as positive control and DMSO as negative control for antifungal activity. Antioxidant activity increasing nature in DPPH than NO radical compared with rutin and confirmed non toxic property using cytotoxicity analysis. The biopolymeric hydrogels were characterized by Fourier transform infrared (FT-IR) spectroscopy, 1H NMR,13C NMR, TGA, DSC followed by scanning electron microscopy (SEM). Such hydrogels with antioxidant properties is recommended for medical applications such as bandages, catheters, drains and tubes to prevent infection.

KEYWORDS:

Antifungal activity; Antioxidant activity; Citric acid; Cytotoxicity; Indole-3-acetic acid; Swelling equilibrium

PMID:
27888010
DOI:
10.1016/j.ijbiomac.2016.11.068
[Indexed for MEDLINE]

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