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J Mycol Med. 2016 Dec;26(4):385-390. doi: 10.1016/j.mycmed.2016.11.001. Epub 2016 Nov 22.

An estimation of burden of serious fungal infections in France.

Author information

1
Centre hospitalier universitaire de Rennes, laboratoire de parasitologie-mycologie, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 09, France. Electronic address: Jean-pierre.gangneux@univ-rennes1.fr.
2
Centre hospitalier universitaire Necker-Enfants-Malades, Assistance publique-Hôpitaux de Paris, laboratoire de parasitologie-mycologie, 149, rue de Sèvres, 75015 Paris, France.
3
Centre hospitalier universitaire Saint-Antoine, Assistance publique-Hôpitaux de Paris, laboratoire de parasitologie-mycologie, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France.
4
Centre hospitalier universitaire de Poitiers, service de médecine interne, maladies infectieuses et tropicales, 2, rue de la Milétrie, 86021 Poitiers, France.
5
Centre hospitalier universitaire de Tours, laboratoire de parasitologie-mycologie, 2, boulevard Tonnellé, 37000 Tours, France.
6
The University of Manchester and National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK.

Abstract

OBJECTIVE OF THE STUDY:

An estimation of burden of serious fungal diseases in France is essential data to inform public health priorities on the importance of resources and research needed on these infections. In France, precise data are available for invasive fungal diseases but estimates for several other diseases such as chronic and immunoallergic diseases are by contrast less known.

MATERIALS AND METHODS:

A systematic literature search was conducted using the Web of Science Platform. Published epidemiology papers reporting fungal infection rates from France were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in those populations to estimate national incidence or prevalence, depending on the condition.

RESULTS:

The model predicts high prevalences of severe asthma with fungal sensitization episodes (189 cases/100,000 adults per year), of allergic bronchopulmonary aspergillosis (145/100,000) and of chronic pulmonary aspergillosis (5.24/100,000). Besides, estimated incidence for invasive aspergillosis is 1.8/100,000 annually based on classical high risk factors. Estimates for invasive mucormycosis, pneumocystosis and cryptococcosis are 0.12/100,000, 1/100,000 and 0.2/100,000, respectively. Regarding invasive candidiasis, more than 10,000 cases per year are estimated, and a much higher number of recurrent vaginal candidiasis is probable but must be confirmed. Finally, this survey was an opportunity to report a first picture of the frequency of tinea capitis in France.

CONCLUSION:

Using local and literature data of the incidence or prevalence of fungal infections, approximately 1,000,000 (1.47%) people in France are estimated to suffer from serious fungal infections each year.

KEYWORDS:

Aspergillose; Aspergillosis; Candidiasis; Candidose; Cryptococcose; Cryptococcosis; France; Mucormycose; Mucormycosis; Pneumocystose; Pneumocystosis; Teigne du cuir chevelu; Tinea capitis

PMID:
27887809
DOI:
10.1016/j.mycmed.2016.11.001
[Indexed for MEDLINE]

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