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J Alzheimers Dis. 2017;56(1):261-273. doi: 10.3233/JAD-160833.

Discriminative Properties of Hippocampal Hypoperfusion in Marijuana Users Compared to Healthy Controls: Implications for Marijuana Administration in Alzheimer's Dementia.

Author information

1
Amen Clinics Inc. Costa Mesa, CA, USA.
2
University of California San Francisco, San Francisco, CA, USA.
3
Department of Electrical Engineering, University of Southern California, Los Angeles, CA, USA.
4
UCLA Medical Center, Los Angeles, CA, USA.

Abstract

BACKGROUND:

Few studies have evaluated the impact of marijuana use on regional cerebral blood flow.

OBJECTIVE:

To determine whether perfusion in specific brain regions on functional neuroimaging, including those affected by Alzheimer's disease pathology, are abnormal in marijuana users compared to controls.

METHOD:

Persons with a diagnosis of cannabis use disorder by DSM-IV and DSM-V criteria (n = 982) were compared to controls (n = 92) with perfusion neuroimaging with SPECT at rest and at a concentration task. Perfusion estimates were quantified using a standard atlas. Cerebral perfusion differences were calculated using one-way ANOVA. Diagnostic separation was determined with discriminant analysis of all subjects. Feature selection with a minimum redundancy maximum relevancy (mRMR) identified predictive regions in a subset of marijuana users (n = 436) with reduced psychiatric co-morbidities.

RESULTS:

Marijuana users showed lower cerebral perfusion on average (p < 0.05). Discriminant analysis distinguished marijuana users from controls with correct classification of 96% and leave one out cross-validation of 92%. With concentration SPECT regions, there was correct classification of 95% with a leave-one-out cross validation of 90%. AUC analysis for concentration SPECT regions showed 95% accuracy, 90% sensitivity, and 83% specificity. The mRMR analysis showed right hippocampal hypoperfusion on concentration SPECT imaging was the most predictive in separating marijuana subjects from controls.

CONCLUSION:

Multiple brain regions show low perfusion on SPECT in marijuana users. The most predictive region distinguishing marijuana users from healthy controls, the hippocampus, is a key target of Alzheimer's disease pathology. This study raises the possibility of deleterious brain effects of marijuana use.

KEYWORDS:

Hippocampus; SPECT; imaging; marijuana

PMID:
27886010
DOI:
10.3233/JAD-160833
[Indexed for MEDLINE]

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